β2 肾上腺素受体激动剂治疗心衰研究进展
Research Progress inβ2 Adrenergic Receptor Agonist for the Treatment of Heart Failure
中文关键词  
DOI:
中文关键词:  慢性心衰  β2 肾上腺素受体  偏向性 β2 肾上腺素受体激动剂
英文关键词:chronic heart failure  β2 adrenergic receptor  biased β2 adrenergic receptor agonist
基金项目:
作者单位
陈艳敏 1 1. 北京大学-清华大学生命科学联合中心,北京 100871;2. 北京大学分子医学研究所,北京 100871 
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中文摘要:
      慢性心衰作为发病率和死亡率很高的一种疾病,其主要表现为心脏供血功能下降,无法满足身体需求。β 肾上腺素受体信号通路对 于维持心脏正常生理功能有重要意义,心衰时,β 肾上腺素受体信号通路也发生很大改变。基于对 β 肾上腺素受体信号通路的机制研究, 目前 β1 肾上腺素受体拮抗剂被广泛应用于心衰治疗,但 β2 肾上腺素受体的功能还有争议。综述 β2 肾上腺素受体在心衰过程中作用的研究 进展,提出 β2 肾上腺素受体激动剂联合 β1 肾上腺素受体拮抗剂治疗心衰的策略,旨在为心衰治疗药物的开发提供参考。
英文摘要:
      Chronic heart failure is a disease with high mobidity and motality and characterized by insuf cient heart output to meet the needs of the body. The beta adrenergic receptor signal pathway plays important roles in the physiological functions of heart. At present, β1-adrenergic receptor (β1AR) blockers are widely used in the treatment of heart failure based on the study of signaling pathway of beta adrenergic receptor. However, the role of β2- adrenergic receptor (β2AR) is still controversial. With the purpose of providing reference for the development of heart failure drugs, this article mainly reviewed recent progress in the role of β2AR in the development of heart failure and proposed the combination of functional biased β2AR agonist with β1AR blocker as a new strategy for the treatment of heart failure.
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